Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Spc25SPC25 component of NDC80 kinetochore complex. (237 aa)    
Predicted Functional Partners:
spc24
SPC24 component of NDC80 kinetochore complex.
   
 0.999
Ndc80
NDC80 kinetochore complex component.
   
 0.999
nuf2
UF2 component of NDC80 kinetochore complex.
   
 0.999
bub1
BUB1 mitotic checkpoint serine/threonine kinase.
   
 0.997
nsl1
NSL1 component of MIS12 kinetochore complex.
   
 0.995
mis12
MIS12 kinetochore complex component.
    
 0.994
bub1b
BUB1 mitotic checkpoint serine/threonine kinase Bb.
   
 0.992
knl1
Knl1_RWD_C domain-containing protein.
   
 0.981
LOC100693963
Si:dkey-6i22.5.
   
  0.980
ENSONIP00000040862
annotation not available
   
 0.978
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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