Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LOC100704738Uncharacterized protein; Belongs to the peptidase S1 family. (430 aa)    
Predicted Functional Partners:
LOC100702313
Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.
   
 0.720
ggcx
Gamma-glutamyl carboxylase.
    
 0.720
serpinc1
Serpin peptidase inhibitor, clade C (antithrombin), member 1; Belongs to the serpin family.
   
 0.713
F3
Coagulation factor IIIa.
    
 0.694
LOC100709933
Uncharacterized protein.
    
 0.684
LOC112844144
Tissue factor pathway inhibitor.
    
 0.668
f5
Coagulation factor V; Belongs to the multicopper oxidase family.
   
 0.630
LOC100698479
Coagulation factor VIII, procoagulant component; Belongs to the multicopper oxidase family.
   
 0.630
serpina10
Si:ch1073-416d2.3; Belongs to the serpin family.
   
 0.582
serpind1
Serpin peptidase inhibitor, clade D (heparin cofactor), member 1; Belongs to the serpin family.
   
 0.530
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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