Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
KRT222Keratin-like protein KRT222 isoform X1. (543 aa)    
Predicted Functional Partners:
I3JRJ3_ORENI
Keratin 5; Belongs to the intermediate filament family.
   
 0.710
UNC79
Unc-79 homolog, NALCN channel complex subunit.
   
 0.691
LOC100702817
Keratin 8; Belongs to the intermediate filament family.
   
 0.595
LOC100705514
Ephrin-A1b; Belongs to the ephrin family.
    
 
 0.585
tradd
Tnfrsf1a-associated via death domain.
    
 
 0.577
RAC2
Rac family small GTPase 2.
   
 0.577
Rasgrf2
Ras protein-specific guanine nucleotide-releasing factor 2b.
    
 0.567
pak2
Non-specific serine/threonine protein kinase.
    
 0.565
LOC100697571
Mitogen-activated protein kinase kinase 2b.
    
 0.561
LOC100711257
Mitogen-activated protein kinase kinase 4b; Belongs to the protein kinase superfamily.
      
 0.553
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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