STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC100696367Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1005 aa)    
Predicted Functional Partners:
I3JV04_ORENI
Translocase of outer mitochondrial membrane 20.
    
 0.776
arid4a
AT rich interactive domain 4A (RBP1-like).
    
 0.776
Prkn
E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.
    
 0.741
ENSONIP00000079948
Uncharacterized protein LOC109194435 isoform X1.
    
 0.715
LOC100692890
RAN binding protein 2.
   
 0.709
I3JR68_ORENI
NME/NM23 family member 8; Belongs to the NDK family.
   
 
 0.702
wdr90
WD repeat domain 90.
   
 0.695
sirt1
Deacetylase sirtuin-type domain-containing protein.
    
 0.693
Camk4
Si:ch73-60h1.1; Belongs to the protein kinase superfamily.
   
 0.686
LOC100706645
Histone H2A; Belongs to the histone H2A family.
   
 0.676
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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