Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
RNF223Ring finger protein 223. (228 aa)    
Predicted Functional Partners:
rnf144a
RBR-type E3 ubiquitin transferase.
    
 0.666
tmem129
Transmembrane protein 129, E3 ubiquitin protein ligase.
      
 0.653
meaf6
MYST/Esa1-associated factor 6.
     
 0.643
I3IUB9_ORENI
RBR-type E3 ubiquitin transferase.
    
 0.619
noc2l
NOC2-like nucleolar associated transcriptional repressor.
     
 0.616
samd11
Sterile alpha motif domain containing 11.
      
 0.509
Perm1
PGC-1 and ERR-induced regulator in muscle protein 1.
    
 0.459
I3KAJ1_ORENI
Uncharacterized protein.
    
 0.459
I3KYR2_ORENI
Ring finger protein 182.
      
 0.447
rnft1
Ring finger protein, transmembrane 1.
     
 0.436
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.