thoc6 protein (Oreochromis niloticus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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Databases

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[Homology]

Score

thoc6

THO complex 6. (394 aa)

Predicted Functional Partners:

thoc1

0.995

thoc5

0.991

thoc3

0.987

thoc7

0.986

Thoc2

0.982

zc3h13

0.954

alyref

0.925

LOC100711348

0.866

LOC100704968

0.866

DDX39A

0.866

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDX39A	Thoc2	ENSONIP00000068117	ENSONIP00000052051	DExD-box helicase 39A.	THO complex 2.	0.959
DDX39A	alyref	ENSONIP00000068117	ENSONIP00000024463	DExD-box helicase 39A.	Aly/REF export factor.	0.945
DDX39A	thoc1	ENSONIP00000068117	ENSONIP00000035853	DExD-box helicase 39A.	THO complex 1.	0.920
DDX39A	thoc3	ENSONIP00000068117	ENSONIP00000071767	DExD-box helicase 39A.	THO complex 3.	0.867
DDX39A	thoc5	ENSONIP00000068117	ENSONIP00000055935	DExD-box helicase 39A.	THO complex 5.	0.917
DDX39A	thoc6	ENSONIP00000068117	ENSONIP00000011722	DExD-box helicase 39A.	THO complex 6.	0.866
DDX39A	thoc7	ENSONIP00000068117	ENSONIP00000060294	DExD-box helicase 39A.	THO complex 7.	0.908
DDX39A	zc3h13	ENSONIP00000068117	ENSONIP00000015412	DExD-box helicase 39A.	Zinc finger CCCH-type containing 13.	0.876
LOC100704968	Thoc2	ENSONIP00000055879	ENSONIP00000052051	Uncharacterized protein.	THO complex 2.	0.959
LOC100704968	alyref	ENSONIP00000055879	ENSONIP00000024463	Uncharacterized protein.	Aly/REF export factor.	0.945
LOC100704968	thoc1	ENSONIP00000055879	ENSONIP00000035853	Uncharacterized protein.	THO complex 1.	0.920
LOC100704968	thoc3	ENSONIP00000055879	ENSONIP00000071767	Uncharacterized protein.	THO complex 3.	0.867
LOC100704968	thoc5	ENSONIP00000055879	ENSONIP00000055935	Uncharacterized protein.	THO complex 5.	0.917
LOC100704968	thoc6	ENSONIP00000055879	ENSONIP00000011722	Uncharacterized protein.	THO complex 6.	0.866
LOC100704968	thoc7	ENSONIP00000055879	ENSONIP00000060294	Uncharacterized protein.	THO complex 7.	0.908
LOC100704968	zc3h13	ENSONIP00000055879	ENSONIP00000015412	Uncharacterized protein.	Zinc finger CCCH-type containing 13.	0.876
LOC100711348	Thoc2	ENSONIP00000028282	ENSONIP00000052051	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B.	THO complex 2.	0.959
LOC100711348	alyref	ENSONIP00000028282	ENSONIP00000024463	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B.	Aly/REF export factor.	0.994
LOC100711348	thoc1	ENSONIP00000028282	ENSONIP00000035853	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B.	THO complex 1.	0.919
LOC100711348	thoc3	ENSONIP00000028282	ENSONIP00000071767	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B.	THO complex 3.	0.867

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.879

expected number of edges:

12

PPI enrichment p-value:

0.000746

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 354

1.79

4.36

4.84e-14

GO:0002183

Cytoplasmic translational initiation

3 of 27

2.39

2.12

0.00010

GO:0006446

Regulation of translational initiation

3 of 52

2.1

1.67

0.00057

GO:0075522

IRES-dependent viral translational initiation

2 of 5

2.94

1.61

0.0012

GO:0001732

Formation of cytoplasmic translation initiation complex

2 of 19

2.36

1.09

0.0097

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003743

Translation initiation factor activity

7 of 53

2.46

6.09

3.62e-13

GO:0043022

Ribosome binding

3 of 72

1.96

1.33

0.0025

GO:0031369

Translation initiation factor binding

2 of 20

2.34

1.02

0.0130

GO:0003735

Structural constituent of ribosome

3 of 176

1.57

0.85

0.0170

GO:0003723

RNA binding

6 of 1158

1.05

0.83

0.0025

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005850

Eukaryotic translation initiation factor 2 complex

3 of 3

3.34

3.19

1.75e-06

GO:0033290

Eukaryotic 48S preinitiation complex

3 of 16

2.61

2.45

2.82e-05

GO:0005840

Ribosome

5 of 203

1.73

2.11

1.25e-05

GO:0015935

Small ribosomal subunit

3 of 49

2.13

1.8

0.00032

GO:0071541

Eukaryotic translation initiation factor 3 complex, eIF3m

2 of 6

2.86

1.67

0.00094

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:18379

Eukaryotic 43S preinitiation complex, and Eukaryotic translation initiation factor 2 complex

4 of 23

2.58

3.09

1.53e-06

CL:18383

Eukaryotic translation initiation factor 3 complex

3 of 11

2.78

2.85

5.49e-06

CL:18365

Translational initiation, and Negative regulation of translational initiation

5 of 86

2.1

2.82

1.53e-06

CL:17695

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

5 of 102

2.03

2.76

1.53e-06

CL:17712

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

3 of 43

2.18

1.89

0.00022

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03013

RNA transport

7 of 283

1.73

3.17

2.11e-09

map03010

Ribosome

3 of 198

1.52

0.95

0.0088

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72695

Formation of the ternary complex, and subsequently, the 43S complex

7 of 64

2.38

5.95

3.31e-13

MAP-72649

Translation initiation complex formation

7 of 70

2.34

5.87

3.31e-13

MAP-72662

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

7 of 74

2.32

5.81

3.38e-13

MAP-72702

Ribosomal scanning and start codon recognition

7 of 77

2.3

5.76

3.77e-13

MAP-72706

GTP hydrolysis and joining of the 60S ribosomal subunit

8 of 129

2.13

5.4

2.41e-13

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005850

Eukaryotic translation initiation factor 2 complex

3 of 8

2.91

2.6

1.80e-05

GOCC:0005852

Eukaryotic translation initiation factor 3 complex

2 of 15

2.47

0.93

0.0198

GOCC:0022627

Cytosolic small ribosomal subunit

2 of 24

2.26

0.88

0.0236

GOCC:0005840

Ribosome

3 of 150

1.64

0.84

0.0205

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0396

Initiation factor

6 of 55

2.38

5.1

3.48e-11

KW-0689

Ribosomal protein

3 of 165

1.6

1.03

0.0065

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08662

Eukaryotic translation initiation factor eIF2A

3 of 3

3.34

3.03

3.31e-06

PF03144

Elongation factor Tu domain 2

2 of 15

2.47

0.83

0.0301

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