STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
npc1Niemann-Pick disease, type C1. (1273 aa)    
Predicted Functional Partners:
npc2
Niemann-Pick disease, type C2.
   
 0.998
srebf2
Sterol regulatory element binding transcription factor 2.
   
 0.841
srebf1
Sterol regulatory element binding transcription factor 1.
   
 0.841
I3KBQ7_ORENI
MYCN proto-oncogene, bHLH transcription factor.
   
 0.810
insig1
Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis.
   
 0.688
insig2
Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.
   
 0.688
gramd1b
GRAM domain containing 1Bb.
      
 0.557
Gramd1c
GRAM domain containing 1c.
      
 0.550
mbtps1
Membrane-bound transcription factor peptidase, site 1.
   
 
 0.547
LOC100705747
Extended synaptotagmin-like protein 3.
   
  
 0.509
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.