Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
npc1Niemann-Pick disease, type C1. (1273 aa)    
Predicted Functional Partners:
npc2
Niemann-Pick disease, type C2.
   
 0.994
srebf2
Sterol regulatory element binding transcription factor 2.
    
 0.856
srebf1
Sterol regulatory element binding transcription factor 1.
    
 0.846
LOC100689819
Oxysterol-binding protein; Belongs to the OSBP family.
   
 0.697
OSBPL8
Oxysterol-binding protein; Belongs to the OSBP family.
   
 0.697
LOC100697646
3-hydroxy-3-methylglutaryl coenzyme A reductase.
   
  
 0.671
insig1
Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis.
    
 0.663
insig2
Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.
    
 0.663
I3KBQ7_ORENI
MYCN proto-oncogene, bHLH transcription factor.
    
 0.632
mbtps1
Membrane-bound transcription factor peptidase, site 1.
   
 
 0.625
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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