Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
cables1Cdk5 and Abl enzyme substrate 1. (542 aa)    
Predicted Functional Partners:
cdk5
Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily.
    
 0.887
mib1
Mindbomb E3 ubiquitin protein ligase 1.
    
 
 0.785
fibp
Fibroblast growth factor (acidic) intracellular binding protein a.
    
 
 0.669
DLK1
Delta like non-canonical Notch ligand 1.
    
   0.593
p53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 
 0.583
ccna2
Cyclin A2; Belongs to the cyclin family.
     
 0.573
ccna1
Cyclin A1; Belongs to the cyclin family.
     
 0.573
cdk2
Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.
   
 0.552
cdk6
Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily.
   
 0.536
LOC100692568
Cyclin E2; Belongs to the cyclin family.
    
 0.535
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.