Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
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[Homology]
Score
Rock1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1353 aa)    
Predicted Functional Partners:
ppp1r12c
Protein phosphatase 1 regulatory subunit.
   
 0.961
LOC100699773
Protein phosphatase 1 regulatory subunit 12B isoform X1.
   
 0.961
I3K382_ORENI
Uncharacterized protein.
    
 0.957
LOC100693040
LIM domain kinase 1a.
    
 0.952
limk2
LIM domain kinase 2.
    
 0.952
LOC100710463
Uncharacterized protein.
    
 0.950
LOC100704692
LIM domain kinase 1b.
    
 0.950
LOC100708845
Uncharacterized protein.
    
 0.950
LOC100697131
Myosin, light chain 9a, regulatory.
    
 0.950
ppp1r12a
Protein phosphatase 1 regulatory subunit.
   
 0.941
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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