Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
lrwd1Leucine-rich repeats and WD repeat domain containing 1. (739 aa)    
Predicted Functional Partners:
orc3
Origin recognition complex, subunit 3.
    
 0.994
Orc4
Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family.
    
 0.994
orc5
Origin recognition complex, subunit 5.
    
 0.993
I3KF05_ORENI
Uncharacterized protein.
    
 0.990
orc1
Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
    
 0.928
vwa5b2
Von Willebrand factor A domain containing 5B2.
    
 
 0.765
ticrr
Treslin_N domain-containing protein.
    
 
 0.712
skp2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase.
    
 0.635
cul1
Cullin 1b; Belongs to the cullin family.
    
  0.629
kif6
Kinesin family member 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
    
 
 0.626
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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