Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
adam8ADAM metallopeptidase domain 8a. (886 aa)    
Predicted Functional Partners:
LGI2
Leucine-rich repeat LGI family, member 2b.
   
 0.466
sh3pxd2a
Uncharacterized protein.
    
 0.455
LOC100693377
SH3 and PX domains 2Aa.
    
 0.455
Sh3pxd2b
SH3 and PX domains 2B.
    
 0.455
HYAL2
Hyaluronidase.
   
 
 0.428
SPAM1
Hyaluronidase.
   
 
 0.428
HYAL2-2
Hyaluronidase.
   
 
 0.428
LOC100702641
Hyaluronoglucosaminidase.
   
 
 0.428
cdh11
Cadherin 11, type 2, OB-cadherin (osteoblast); Cadherins are calcium-dependent cell adhesion proteins.
   
 
 0.406
CDH8
Cadherin 8; Cadherins are calcium-dependent cell adhesion proteins.
   
 
 0.406
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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