close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
irf4Interferon regulatory factor 4a. (460 aa)    
Predicted Functional Partners:
LOC100704899
Interferon regulatory factor.
  
0.625
spi1
Spi-1 proto-oncogene b.
   
 
 0.532
LOC100704522
Zinc finger protein 366.
    
 0.520
myd88
Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
   
 0.508
mrc2
Mannose receptor, C type 2.
    
 
 0.487
il7r
Fibronectin type-III domain-containing protein.
   
 
 0.486
ENSONIP00000036848
Receptor-type tyrosine-protein kinase FLT3.
    
 
 0.483
gata3
GATA binding protein 3.
    
 0.475
CDC25B
Cell division cycle 25B.
   
 0.454
ptprc
Protein tyrosine phosphatase receptor type C.
   
 0.449
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.