Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LOC100707163Vinculin a. (1158 aa)    
Predicted Functional Partners:
LOC100711808
Talin 1.
   
 0.985
I3J2M2_ORENI
Talin 2a.
   
 0.977
tln2
Talin 2b.
   
 0.977
I3JVA1_ORENI
Sorbin and SH3 domain containing 2a.
   
 0.952
LOC100706266
Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family.
   
 0.949
ENSONIP00000069782
Paxillin b.
   
 0.949
ctnnb1
Catenin (cadherin-associated protein), beta 1.
   
 0.941
LOC100702030
Vinexin isoform X1.
   
 0.931
I3JVU5_ORENI
Sorbin and SH3 domain containing 1.
   
 0.931
ctnna2
Catenin (cadherin-associated protein), alpha 2.
   
 0.927
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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