Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
arhgef4Uncharacterized protein. (653 aa)    
Predicted Functional Partners:
apc2
APC regulator of WNT signaling pathway 2.
   
 0.948
cdc42
Cell division cycle 42.
    
 0.885
LOC100701814
Spermatogenesis associated 13.
     
  0.866
RAC2
Rac family small GTPase 2.
    
 0.735
LOC100696401
Ras-related C3 botulinum toxin substrate 1-like.
    
 0.735
RAC1
Rac family small GTPase 1.
    
 0.735
ENSONIP00000057298
Rac family small GTPase 3b.
    
 0.735
LOC100707935
Rho related BTB domain containing 4.
    
 0.691
ENSONIP00000000682
Intersectin 2a.
    
 0.654
I3KKD0_ORENI
Intersectin 2b.
    
 0.654
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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