Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
steap2STEAP family member 2, metalloreductase. (512 aa)    
Predicted Functional Partners:
LOC100689723
BCL2 interacting protein 3 like b.
    
 0.704
LOC100711031
BCL2 interacting protein 3 like a.
    
 0.704
urod
Uroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family.
      
 0.579
p53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.575
LOC100707936
Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.
      
 0.574
LOC100702684
Ceruloplasmin; Belongs to the multicopper oxidase family.
   
  
 0.534
bnip3
BCL2 interacting protein 3.
    
 0.527
LAMA2
Laminin subunit alpha 2.
      
 0.523
LOC100702432
Uncharacterized protein.
      
 0.522
sqor
Sulfide quinone oxidoreductase.
      
 0.522
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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