hsd3b7 protein (Oreochromis niloticus) - STRING interaction network

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hsd3b7

Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase; Belongs to the 3-beta-HSD family. (366 aa)

Predicted Functional Partners:

I3K981_ORENI

0.973

LOC100709377

0.962

Srd5a3

0.937

hsd17b3

0.908

AKR1D1

0.885

LOC109194203

0.885

hsd11b2

0.873

I3KE17_ORENI

0.858

LOC100702293

0.849

hsd17b8

0.848

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKR1D1	I3KE17_ORENI	ENSONIP00000011128	ENSONIP00000058778	Aldo-keto reductase family 1 member D1.	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	0.504
AKR1D1	LOC100709377	ENSONIP00000011128	ENSONIP00000041817	Aldo-keto reductase family 1 member D1.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.737
AKR1D1	Srd5a3	ENSONIP00000011128	ENSONIP00000043906	Aldo-keto reductase family 1 member D1.	3-oxo-5-alpha-steroid 4-dehydrogenase 3 / polyprenol reductase.	0.887
AKR1D1	hsd11b2	ENSONIP00000011128	ENSONIP00000004099	Aldo-keto reductase family 1 member D1.	11-beta hydroxysteroid dehydrogenase type 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.904
AKR1D1	hsd17b3	ENSONIP00000011128	ENSONIP00000019062	Aldo-keto reductase family 1 member D1.	Hydroxysteroid (17-beta) dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.878
AKR1D1	hsd17b8	ENSONIP00000011128	ENSONIP00000025236	Aldo-keto reductase family 1 member D1.	Hydroxysteroid (17-beta) dehydrogenase 8.	0.922
AKR1D1	hsd3b7	ENSONIP00000011128	ENSONIP00000012375	Aldo-keto reductase family 1 member D1.	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase; Belongs to the 3-beta-HSD family.	0.885
I3K981_ORENI	I3KE17_ORENI	ENSONIP00000039897	ENSONIP00000058778	Cytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family.	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	0.967
I3K981_ORENI	hsd3b7	ENSONIP00000039897	ENSONIP00000012375	Cytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family.	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase; Belongs to the 3-beta-HSD family.	0.973
I3KE17_ORENI	AKR1D1	ENSONIP00000058778	ENSONIP00000011128	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Aldo-keto reductase family 1 member D1.	0.504
I3KE17_ORENI	I3K981_ORENI	ENSONIP00000058778	ENSONIP00000039897	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family.	0.967
I3KE17_ORENI	LOC100709377	ENSONIP00000058778	ENSONIP00000041817	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.603
I3KE17_ORENI	LOC109194203	ENSONIP00000058778	ENSONIP00000036928	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Aldo_ket_red domain-containing protein.	0.504
I3KE17_ORENI	Srd5a3	ENSONIP00000058778	ENSONIP00000043906	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	3-oxo-5-alpha-steroid 4-dehydrogenase 3 / polyprenol reductase.	0.894
I3KE17_ORENI	hsd11b2	ENSONIP00000058778	ENSONIP00000004099	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	11-beta hydroxysteroid dehydrogenase type 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.900
I3KE17_ORENI	hsd17b3	ENSONIP00000058778	ENSONIP00000019062	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Hydroxysteroid (17-beta) dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.937
I3KE17_ORENI	hsd17b8	ENSONIP00000058778	ENSONIP00000025236	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Hydroxysteroid (17-beta) dehydrogenase 8.	0.859
I3KE17_ORENI	hsd3b7	ENSONIP00000058778	ENSONIP00000012375	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase; Belongs to the 3-beta-HSD family.	0.858
LOC100702293	hsd3b7	ENSONIP00000024904	ENSONIP00000012375	Cytochrome P450, family 51; Belongs to the cytochrome P450 family.	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase; Belongs to the 3-beta-HSD family.	0.849
LOC100709377	AKR1D1	ENSONIP00000041817	ENSONIP00000011128	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	Aldo-keto reductase family 1 member D1.	0.737

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