Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SLC25A42Solute carrier family 25 member 42; Belongs to the mitochondrial carrier (TC 2.A.29) family. (326 aa)    
Predicted Functional Partners:
rpl18
60S ribosomal protein L18; Component of the large ribosomal subunit.
 
 
    0.902
tyms
Thymidylate synthetase.
  
 0.848
Tk1
Thymidine kinase.
   
 
 0.791
pcna
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
  
  
 0.785
dtymk
Deoxythymidylate kinase (thymidylate kinase).
  
 
 0.778
ENSONIP00000016918
Adenylate kinase 9.
  
 0.771
itpa
Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.
  
 0.757
rfc3
Replication factor C (activator 1) 3.
   
 
 0.724
ppcs
Phosphopantothenoylcysteine synthetase.
  
 
 0.720
MRPL58
Mitochondrial ribosomal protein L58.
  
  
 0.708
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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