Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LOC100703629Toll-like receptor 3; Belongs to the Toll-like receptor family. (912 aa)    
Predicted Functional Partners:
myd88
Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
    
 0.987
LOC100701239
TRIF-NTD domain-containing protein.
    
 0.960
LOC100701005
Transmembrane p24 trafficking protein 7.
    
 0.922
traf6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.910
LOC100702954
Interferon regulatory factor 3.
    
 0.906
irak4
Interleukin-1 receptor-associated kinase 4.
    
 0.882
LOC100709769
Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
   
 0.832
irak1
Interleukin-1 receptor-associated kinase 1.
    
 0.815
tirap
Toll-interleukin 1 receptor (TIR) domain containing adaptor protein.
   
 0.807
tbk1
TANK-binding kinase 1.
   
 0.799
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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