Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
herc4HECT and RLD domain containing E3 ubiquitin protein ligase 4. (1022 aa)    
Predicted Functional Partners:
LOC100708998
UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.801
Fam13a
Family with sequence similarity 13 member A.
      
 0.751
MYPN
Myopalladin isoform X1.
      
 0.730
p53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.709
nup133
Nucleoporin 133.
   
  
 0.696
smchd1
Structural maintenance of chromosomes flexible hinge domain containing 1.
   
  
 0.686
trip12
Thyroid hormone receptor interactor 12.
   
 
 0.665
ctnnb1
Catenin (cadherin-associated protein), beta 1.
    
 0.646
tsc2
Rap-GAP domain-containing protein.
    
 0.633
rps27a
Ribosomal protein S27a.
    
 0.627
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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