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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sirt1Deacetylase sirtuin-type domain-containing protein. (712 aa)    
Predicted Functional Partners:
p53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.995
foxo3
Forkhead box O3b.
    
 0.987
LOC100706370
Fork-head domain-containing protein.
    
 0.987
nampt
Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family.
     
 0.966
nadsyn1
Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.
    
 0.955
LOC100696396
Forkhead box O6 b.
    
 0.935
nudt12
Nudix (nucleoside diphosphate linked moiety X)-type motif 12.
    
 0.913
LOC100706113
Nicotinamide nucleotide transhydrogenase.
   
 
 0.903
LOC100699966
Nicotinamide nucleotide transhydrogenase 2.
   
 
 0.903
LOC100709923
Uncharacterized protein.
    
  0.900
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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