Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ppm1dProtein phosphatase, Mg2+/Mn2+ dependent, 1Da. (557 aa)    
Predicted Functional Partners:
p53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 
 0.943
LOC100702285
Protein phosphatase, Mg2+/Mn2+ dependent, 1Db.
     
  0.916
Chek2
Checkpoint kinase 2.
    
 
 0.746
I3JR68_ORENI
NME/NM23 family member 8; Belongs to the NDK family.
  
 0.712
cbfb
Core-binding factor subunit beta.
     
 0.644
ENSONIP00000069434
annotation not available
   
 
 0.633
traf7
TNF receptor-associated factor 7.
   
 0.600
appbp2
Amyloid beta precursor protein (cytoplasmic tail) binding protein 2.
   
 0.594
wdr90
WD repeat domain 90.
    
   0.593
LOC100691239
Runt-related transcription factor.
    
 0.568
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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