Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
appbp2Amyloid beta precursor protein (cytoplasmic tail) binding protein 2. (588 aa)    
Predicted Functional Partners:
cul2
Cullin 2; Belongs to the cullin family.
   
 0.957
eloc
Elongin C paralog a; Belongs to the SKP1 family.
   
 0.935
cops3
COP9 signalosome subunit 3.
    
  0.931
cops2
COP9 signalosome subunit 2.
    
  0.927
HPS6
HPS6 biogenesis of lysosomal organelles complex 2 subunit 3.
      
 0.898
rbx1
Ring-box 1, E3 ubiquitin protein ligase.
    
 0.816
mrpl28
Mitochondrial ribosomal protein L28.
    
   0.777
APP
Amyloid beta precursor protein.
   
 0.775
LOC100709268
Amyloid beta (A4) precursor protein b.
   
 0.775
klhdc3
Kelch domain containing 3.
      
 0.765
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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