Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
angptl4Angiopoietin-like 4. (470 aa)    
Predicted Functional Partners:
LOC100707733
Uncharacterized protein.
     
  0.916
angptl3
Angiopoietin-like 3.
     
 0.842
lpl
Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.
     
 0.665
LOC100689908
PLAT domain-containing protein.
     
 0.665
pdgfc
Platelet derived growth factor c; Belongs to the PDGF/VEGF growth factor family.
      
 0.644
ENSONIP00000079948
Uncharacterized protein LOC109194435 isoform X1.
    
  0.618
Vegfb
PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.
      
 0.612
ctnnb1
Catenin (cadherin-associated protein), beta 1.
   
 
 0.583
LOC100695750
Catenin (cadherin-associated protein), delta 1.
     
  0.572
CTNND1
Catenin delta 1.
     
  0.572
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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