Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LOC102075588TGF_BETA_2 domain-containing protein. (299 aa)    
Predicted Functional Partners:
I3IWI9_ORENI
Nerve growth factor receptor a (TNFR superfamily, member 16).
     
 0.913
ret
Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.
     
  0.909
pdgfrb
Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.
     
  0.909
LOC100691074
Nerve growth factor receptor b.
     
  0.909
tie1
Tyrosine kinase with immunoglobulin-like and EGF-like domains 1.
     
  0.909
LOC100703653
Receptor protein-tyrosine kinase.
     
  0.903
flt1
Uncharacterized protein.
     
  0.903
Fgfr2
Fibroblast growth factor receptor.
     
  0.903
LOC100690421
Receptor protein-tyrosine kinase.
     
  0.903
met
MET proto-oncogene, receptor tyrosine kinase.
     
  0.903
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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