Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
LOC100698183Growth factor independent 1A transcription repressor a. (397 aa)    
Predicted Functional Partners:
Kdm1a
Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.
    
 0.772
myb
V-myb avian myeloblastosis viral oncogene homolog.
   
 0.721
lmo2
LIM domain only 2 (rhombotin-like 1).
   
 0.683
brca1
Uncharacterized protein.
    
 0.602
spi1
Spi-1 proto-oncogene b.
    
 0.553
LOC100696076
GATA binding protein 1a.
   
 0.512
LOC112841626
Erythroid transcription factor-like isoform X1.
   
 0.512
dr1
Down-regulator of transcription 1.
    
 
 0.503
rcor1
REST corepressor 1.
    
 0.488
I3KGS0_ORENI
REST corepressor 3.
    
 0.485
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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