notch1 protein (Oreochromis niloticus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

notch1

Notch receptor 1b. (2519 aa)

Predicted Functional Partners:

maml1

0.993

LOC106098755

0.972

rbpj

0.972

maml2

0.969

numb

0.964

LOC100693976

0.964

NCSTN

0.960

jag1

0.959

LOC100697238

0.958

LOC100710620

0.958

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC100693976	LOC100697238	ENSONIP00000059939	ENSONIP00000000476	NUMB like endocytic adaptor protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.431
LOC100693976	LOC100710620	ENSONIP00000059939	ENSONIP00000029298	NUMB like endocytic adaptor protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.431
LOC100693976	NCSTN	ENSONIP00000059939	ENSONIP00000035581	NUMB like endocytic adaptor protein.	Nicastrin.	0.587
LOC100693976	jag1	ENSONIP00000059939	ENSONIP00000047710	NUMB like endocytic adaptor protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.484
LOC100693976	notch1	ENSONIP00000059939	ENSONIP00000013435	NUMB like endocytic adaptor protein.	Notch receptor 1b.	0.964
LOC100693976	numb	ENSONIP00000059939	ENSONIP00000044499	NUMB like endocytic adaptor protein.	NUMB endocytic adaptor protein.	0.916
LOC100697238	LOC100693976	ENSONIP00000000476	ENSONIP00000059939	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	NUMB like endocytic adaptor protein.	0.431
LOC100697238	LOC100710620	ENSONIP00000000476	ENSONIP00000029298	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.962
LOC100697238	NCSTN	ENSONIP00000000476	ENSONIP00000035581	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Nicastrin.	0.993
LOC100697238	jag1	ENSONIP00000000476	ENSONIP00000047710	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.451
LOC100697238	notch1	ENSONIP00000000476	ENSONIP00000013435	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Notch receptor 1b.	0.958
LOC100697238	numb	ENSONIP00000000476	ENSONIP00000044499	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	NUMB endocytic adaptor protein.	0.431
LOC100710620	LOC100693976	ENSONIP00000029298	ENSONIP00000059939	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	NUMB like endocytic adaptor protein.	0.431
LOC100710620	LOC100697238	ENSONIP00000029298	ENSONIP00000000476	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.962
LOC100710620	NCSTN	ENSONIP00000029298	ENSONIP00000035581	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Nicastrin.	0.995
LOC100710620	jag1	ENSONIP00000029298	ENSONIP00000047710	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.451
LOC100710620	notch1	ENSONIP00000029298	ENSONIP00000013435	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Notch receptor 1b.	0.958
LOC100710620	numb	ENSONIP00000029298	ENSONIP00000044499	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	NUMB endocytic adaptor protein.	0.431
LOC106098755	jag1	ENSONIP00000032353	ENSONIP00000047710	Recombination signal binding protein for immunoglobulin kappa J region a.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.627
LOC106098755	maml1	ENSONIP00000032353	ENSONIP00000005442	Recombination signal binding protein for immunoglobulin kappa J region a.	Mastermind-like transcriptional coactivator 1.	0.995