Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
inpp5eInositol polyphosphate-5-phosphatase E. (641 aa)    
Predicted Functional Partners:
pde6d
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...]
    
 0.997
arl13b
ADP-ribosylation factor-like 13b.
     
 0.984
SACM1L
SAC1 like phosphatidylinositide phosphatase.
    
 0.935
I3JAQ2_ORENI
SAC1 like phosphatidylinositide phosphatase a.
    
 0.935
LOC100707864
Phosphatidylinositol-4-phosphate 5-kinase, type I, beta b.
     
 0.934
LOC100698290
Phosphatidylinositol-4-phosphate 5-kinase, type I, beta a.
     
 0.934
inpp5b
Inositol polyphosphate-5-phosphatase B.
     
 0.932
ocrl
OCRL inositol polyphosphate-5-phosphatase.
     
 0.932
LOC100710015
Uncharacterized protein.
    
 0.928
synj1
Synaptojanin 1.
    
 0.927
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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