LOC100706525 protein (Oreochromis niloticus)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

LOC100706525

Arrestin domain containing 3b. (417 aa)

Predicted Functional Partners:

LOC100690837

0.603

LOC100692536

0.603

LOC100692805

0.603

I3JR68_ORENI

0.426

ENSONIP00000077471

0.408

ENSONIP00000078755

0.408

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSONIP00000077471	LOC100706525	ENSONIP00000077471	ENSONIP00000014324	annotation not available	Arrestin domain containing 3b.	0.408
ENSONIP00000078755	LOC100706525	ENSONIP00000078755	ENSONIP00000014324	annotation not available	Arrestin domain containing 3b.	0.408
I3JR68_ORENI	LOC100706525	ENSONIP00000011362	ENSONIP00000014324	NME/NM23 family member 8; Belongs to the NDK family.	Arrestin domain containing 3b.	0.426
LOC100690837	LOC100706525	ENSONIP00000016241	ENSONIP00000014324	Thioredoxin; Belongs to the thioredoxin family.	Arrestin domain containing 3b.	0.603
LOC100692536	LOC100706525	ENSONIP00000029585	ENSONIP00000014324	Thioredoxin; Belongs to the thioredoxin family.	Arrestin domain containing 3b.	0.603
LOC100692805	LOC100706525	ENSONIP00000058629	ENSONIP00000014324	Thioredoxin; Belongs to the thioredoxin family.	Arrestin domain containing 3b.	0.603
LOC100706525	ENSONIP00000077471	ENSONIP00000014324	ENSONIP00000077471	Arrestin domain containing 3b.	annotation not available	0.408
LOC100706525	ENSONIP00000078755	ENSONIP00000014324	ENSONIP00000078755	Arrestin domain containing 3b.	annotation not available	0.408
LOC100706525	I3JR68_ORENI	ENSONIP00000014324	ENSONIP00000011362	Arrestin domain containing 3b.	NME/NM23 family member 8; Belongs to the NDK family.	0.426
LOC100706525	LOC100690837	ENSONIP00000014324	ENSONIP00000016241	Arrestin domain containing 3b.	Thioredoxin; Belongs to the thioredoxin family.	0.603
LOC100706525	LOC100692536	ENSONIP00000014324	ENSONIP00000029585	Arrestin domain containing 3b.	Thioredoxin; Belongs to the thioredoxin family.	0.603
LOC100706525	LOC100692805	ENSONIP00000014324	ENSONIP00000058629	Arrestin domain containing 3b.	Thioredoxin; Belongs to the thioredoxin family.	0.603

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.85

expected number of edges:

13

PPI enrichment p-value:

8.69e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006096

Glycolytic process

10 of 21

2.61

9.97

1.28e-21

GO:0019693

Ribose phosphate metabolic process

11 of 126

1.87

5.58

1.03e-18

GO:0006006

Glucose metabolic process

4 of 20

2.23

3.0

1.01e-06

GO:0005975

Carbohydrate metabolic process

11 of 363

1.41

2.75

5.19e-14

GO:0006094

Gluconeogenesis

3 of 9

2.45

2.47

2.12e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004332

Fructose-bisphosphate aldolase activity

4 of 6

2.75

3.48

3.37e-07

GO:0016861

Intramolecular oxidoreductase activity, interconverting aldoses and ketoses

3 of 11

2.36

1.93

0.00023

GO:0004807

Triose-phosphate isomerase activity

2 of 2

2.93

1.56

0.0015

GO:0016829

Lyase activity

5 of 177

1.38

1.31

0.00035

GO:0016853

Isomerase activity

4 of 98

1.54

1.29

0.0011

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10783

Glycolytic process, and Glucoamylase

10 of 18

2.67

10.54

1.79e-22

CL:10787

Glycolytic process

9 of 13

2.77

10.09

7.88e-21

CL:10790

Gluconeogenesis, and Glyceraldehyde/Erythrose phosphate dehydrogenase family

4 of 5

2.83

4.1

2.46e-08

CL:10803

Fructose-bisphosphate aldolase activity, and Tetratricopeptide repeat

3 of 5

2.71

2.67

1.15e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00010

Glycolysis / Gluconeogenesis

9 of 82

1.97

5.32

4.44e-15

map00680

Methane metabolism

5 of 39

2.04

3.41

3.19e-08

map01200

Carbon metabolism

9 of 192

1.6

3.29

3.41e-12

map01230

Biosynthesis of amino acids

8 of 230

1.47

2.49

1.26e-09

map00051

Fructose and mannose metabolism

4 of 70

1.68

1.96

2.52e-05

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-70171

Glycolysis

6 of 23

2.34

4.71

2.22e-10

MAP-70326

Glucose metabolism

6 of 107

1.68

2.43

5.68e-07

MAP-70263

Gluconeogenesis

5 of 91

1.67

2.02

1.42e-05

MAP-71387

Metabolism of carbohydrates

6 of 235

1.33

1.51

2.70e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0324

Glycolysis

5 of 13

2.51

4.51

1.63e-09

KW-0312

Gluconeogenesis

3 of 3

2.93

3.02

2.97e-06

KW-0413

Isomerase

3 of 48

1.72

1.29

0.0020

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00121

Triosephosphate isomerase

2 of 2

2.93

1.18

0.0074

PF01116

Fructose-bisphosphate aldolase class-II

2 of 3

2.75

1.17

0.0074

PF14833

NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase

2 of 6

2.45

1.06

0.0114

PF03446

NAD binding domain of 6-phosphogluconate dehydrogenase

2 of 9

2.27

0.96

0.0168

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013785

Aldolase-type TIM barrel

4 of 73

1.67

1.15

0.0038

IPR035990

Triosephosphate isomerase superfamily

2 of 2

2.93

1.1

0.0105

IPR000652

Triosephosphate isomerase

2 of 2

2.93

1.1

0.0105

IPR000771

Fructose-bisphosphate aldolase, class-II

2 of 3

2.75

1.09

0.0105

IPR029154

3-hydroxyisobutyrate dehydrogenase-like, NAD-binding domain

2 of 6

2.45

0.94

0.0195

(more ...)

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