STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ccna1Cyclin A1; Belongs to the cyclin family. (396 aa)    
Predicted Functional Partners:
cdc6
Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.
   
 0.998
cdk1
Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.
   
 0.989
rb1
Retinoblastoma 1.
   
 0.987
e2f1
E2F transcription factor 1.
   
 0.986
cdkn1b
Cyclin-dependent kinase inhibitor 1Bb.
    
 0.977
LOC100711644
Cyclin-dependent kinase inhibitor 1Cb.
    
 0.977
LOC100698501
Uncharacterized protein.
    
 0.977
LOC102082412
Cyclin-dependent kinase inhibitor 1A.
    
 0.977
e2f2
Si:ch211-160f23.5.
   
 0.976
ENSONIP00000041766
Cyclin-dependent kinase inhibitor 1B.
    
 0.973
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.