STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
itkTyrosine-protein kinase. (617 aa)    
Predicted Functional Partners:
LOC100705099
CRK proto-oncogene, adaptor protein.
    
 0.768
itsn1
Intersectin 1 (SH3 domain protein).
    
 0.687
cd247
T-cell surface glycoprotein CD3 zeta chain.
   
 0.642
grb2
Growth factor receptor-bound protein 2b.
   
 0.618
htt
Huntingtin.
    
 0.607
LOC100693204
B cell linker.
   
 0.600
syk
Tyrosine-protein kinase.
  
0.574
LOC100696446
Tyrosine-protein kinase.
  
0.572
LOC100701740
Macrophage stimulating 1 receptor a.
    
 
0.569
mst1r
Macrophage stimulating 1 receptor b.
    
 
0.569
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.