STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
egfrReceptor protein-tyrosine kinase. (1206 aa)    
Predicted Functional Partners:
egf
Epidermal growth factor.
   
 0.985
LOC100709722
EGF-like domain-containing protein.
    
 0.974
LOC100692645
Uncharacterized protein.
    
 0.972
I3KEF4_ORENI
Uncharacterized protein.
    
 0.972
shc1
SHC (Src homology 2 domain containing) transforming protein 1.
    
 0.971
SHC3
SHC adaptor protein 3.
    
 0.971
LOC100691361
Heparin-binding EGF-like growth factor a.
    
 0.968
tgfa
Transforming growth factor, alpha.
    
 0.967
LOC100696779
SHC (Src homology 2 domain containing) transforming protein 2.
    
 0.961
Plcg2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.
    
 0.958
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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