rgs3 protein (Oreochromis niloticus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

rgs3

Regulator of G-protein signaling 3 isoform X1. (1190 aa)

Predicted Functional Partners:

LOC100702054

0.635

apc2

0.623

LOC100703259

0.582

LOC100706288

0.582

cct5

0.572

gnb4

0.559

LOC100703896

0.559

LOC100692028

0.559

LOC100691200

0.559

gnb1

0.559

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC100691200	LOC100703259	ENSONIP00000016349	ENSONIP00000003131	Guanine nucleotide binding protein (G protein), beta polypeptide 3a.	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2.	0.683
LOC100691200	LOC100706288	ENSONIP00000016349	ENSONIP00000005117	Guanine nucleotide binding protein (G protein), beta polypeptide 3a.	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1.	0.646
LOC100691200	cct5	ENSONIP00000016349	ENSONIP00000028175	Guanine nucleotide binding protein (G protein), beta polypeptide 3a.	Chaperonin containing TCP1, subunit 5 (epsilon).	0.751
LOC100691200	rgs3	ENSONIP00000016349	ENSONIP00000034110	Guanine nucleotide binding protein (G protein), beta polypeptide 3a.	Regulator of G-protein signaling 3 isoform X1.	0.559
LOC100692028	LOC100702054	ENSONIP00000005292	ENSONIP00000003304	Guanine nucleotide binding protein (G protein), beta polypeptide 2.	Guanine nucleotide binding protein (G protein), beta 5b.	0.476
LOC100692028	LOC100703259	ENSONIP00000005292	ENSONIP00000003131	Guanine nucleotide binding protein (G protein), beta polypeptide 2.	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2.	0.775
LOC100692028	LOC100706288	ENSONIP00000005292	ENSONIP00000005117	Guanine nucleotide binding protein (G protein), beta polypeptide 2.	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1.	0.775
LOC100692028	cct5	ENSONIP00000005292	ENSONIP00000028175	Guanine nucleotide binding protein (G protein), beta polypeptide 2.	Chaperonin containing TCP1, subunit 5 (epsilon).	0.760
LOC100692028	rgs3	ENSONIP00000005292	ENSONIP00000034110	Guanine nucleotide binding protein (G protein), beta polypeptide 2.	Regulator of G-protein signaling 3 isoform X1.	0.559
LOC100702054	LOC100692028	ENSONIP00000003304	ENSONIP00000005292	Guanine nucleotide binding protein (G protein), beta 5b.	Guanine nucleotide binding protein (G protein), beta polypeptide 2.	0.476
LOC100702054	LOC100703259	ENSONIP00000003304	ENSONIP00000003131	Guanine nucleotide binding protein (G protein), beta 5b.	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2.	0.772
LOC100702054	LOC100703896	ENSONIP00000003304	ENSONIP00000005072	Guanine nucleotide binding protein (G protein), beta 5b.	Guanine nucleotide binding protein (G protein), beta polypeptide 1b.	0.482
LOC100702054	LOC100706288	ENSONIP00000003304	ENSONIP00000005117	Guanine nucleotide binding protein (G protein), beta 5b.	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1.	0.772
LOC100702054	cct5	ENSONIP00000003304	ENSONIP00000028175	Guanine nucleotide binding protein (G protein), beta 5b.	Chaperonin containing TCP1, subunit 5 (epsilon).	0.977
LOC100702054	gnb1	ENSONIP00000003304	ENSONIP00000076009	Guanine nucleotide binding protein (G protein), beta 5b.	Guanine nucleotide binding protein (G protein), beta polypeptide 1a.	0.481
LOC100702054	gnb4	ENSONIP00000003304	ENSONIP00000002092	Guanine nucleotide binding protein (G protein), beta 5b.	Guanine nucleotide binding protein (G protein), beta polypeptide 4b.	0.474
LOC100702054	rgs3	ENSONIP00000003304	ENSONIP00000034110	Guanine nucleotide binding protein (G protein), beta 5b.	Regulator of G-protein signaling 3 isoform X1.	0.635
LOC100703259	LOC100691200	ENSONIP00000003131	ENSONIP00000016349	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2.	Guanine nucleotide binding protein (G protein), beta polypeptide 3a.	0.683
LOC100703259	LOC100692028	ENSONIP00000003131	ENSONIP00000005292	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2.	Guanine nucleotide binding protein (G protein), beta polypeptide 2.	0.775
LOC100703259	LOC100702054	ENSONIP00000003131	ENSONIP00000003304	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2.	Guanine nucleotide binding protein (G protein), beta 5b.	0.772

page 1 of 4

Network Stats

number of nodes:

3

number of edges:

3

average node degree:

2

avg. local clustering coefficient:

1

expected number of edges:

2

PPI enrichment p-value:

0.211

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098719

Sodium ion import across plasma membrane

5 of 10

3.04

5.3

1.66e-10

GO:0051453

Regulation of intracellular pH

5 of 65

2.23

3.21

3.32e-07

GO:0014067

Negative regulation of phosphatidylinositol 3-kinase signaling

3 of 6

3.04

2.96

4.14e-06

GO:0072657

Protein localization to membrane

4 of 333

1.42

1.07

0.0030

GO:0072659

Protein localization to plasma membrane

3 of 145

1.66

1.01

0.0082

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015385

Sodium:proton antiporter activity

5 of 11

3.0

5.46

7.96e-11

GO:0015386

Potassium:proton antiporter activity

5 of 14

2.89

5.34

1.06e-10

GO:0043495

Protein-membrane adaptor activity

3 of 26

2.4

2.32

4.04e-05

GO:0008013

Beta-catenin binding

3 of 58

2.05

1.77

0.00032

GO:0030674

Protein-macromolecule adaptor activity

4 of 304

1.46

1.25

0.00098

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098858

Actin-based cell projection

3 of 138

1.68

0.93

0.0129

GO:0016324

Apical plasma membrane

3 of 210

1.5

0.72

0.0330

GO:0005886

Plasma membrane

10 of 5545

0.6

0.44

0.0046

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:32013

Mixed, incl. Sodium ion import across plasma membrane, and Positive regulation of early endosome to late endosome transport

9 of 18

3.04

11.41

1.68e-22

CL:32014

Mixed, incl. Positive regulation of early endosome to late endosome transport, and Negative regulation of phosphatidylinositol 3-kinase signaling

6 of 12

3.04

7.2

3.87e-14

CL:32016

EBP50, C-terminal, and Positive regulation of early endosome to late endosome transport

3 of 5

3.12

2.98

3.89e-06

CL:32037

Mixed, incl. Regulatory region of Na+/H+ exchanger NHE binds to calmodulin, and Cellular response to acidic pH

3 of 6

3.04

2.92

4.86e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04810

Regulation of actin cytoskeleton

5 of 343

1.5

1.66

5.13e-05

map04260

Cardiac muscle contraction

3 of 176

1.57

1.03

0.0062

map04371

Apelin signaling pathway

3 of 230

1.46

0.92

0.0091

map04530

Tight junction

3 of 275

1.38

0.86

0.0114

map04261

Adrenergic signaling in cardiomyocytes

3 of 283

1.37

0.85

0.0114

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-425986

Sodium/Proton exchangers

5 of 11

3.0

5.56

4.97e-11

MAP-425393

Transport of inorganic cations/anions and amino acids/oligopeptides

5 of 191

1.76

2.14

1.25e-05

MAP-425407

SLC-mediated transmembrane transport

5 of 431

1.4

1.3

0.00045

MAP-2160916

Hyaluronan uptake and degradation

2 of 14

2.5

1.11

0.0094

MAP-2142845

Hyaluronan metabolism

2 of 29

2.18

0.83

0.0292

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005902

Microvillus

3 of 33

2.3

1.65

0.00077

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0050

Antiport

5 of 13

2.93

5.71

2.17e-11

KW-0739

Sodium transport

5 of 23

2.68

5.18

1.24e-10

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00999

Sodium/hydrogen exchanger family

5 of 14

2.89

5.22

1.86e-10

PF16644

Regulatory region of Na+/H+ exchanger NHE binds to calmodulin

4 of 4

3.34

4.8

1.93e-09

PF09007

EBP50, C-terminal

2 of 2

3.34

1.69

0.00089

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