STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
I3JEG4_ORENINEDD4 E3 ubiquitin protein ligase a. (960 aa)    
Predicted Functional Partners:
rps27a
Ribosomal protein S27a.
    
 0.850
arrdc3
Arrestin domain containing 3a.
    
 
 0.810
ENSONIP00000047919
Ubiquitin B.
    
 0.800
uba52
Ubiquitin A-52 residue ribosomal protein fusion product 1.
    
 0.767
smad7
Mothers against decapentaplegic homolog.
    
 0.726
LOC100698095
Mothers against decapentaplegic homolog.
    
 0.726
smad6
Mothers against decapentaplegic homolog.
    
 0.726
ndfip2
Nedd4 family interacting protein 2.
    
 
 0.713
smad3
Mothers against decapentaplegic homolog.
    
 0.711
LOC100710325
Mothers against decapentaplegic homolog.
    
 0.711
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.