LOC100534433 protein (Oreochromis niloticus)

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Predicted Interactions

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LOC100534433

Aldo-keto reductase family 1, member A1a (aldehyde reductase). (324 aa)

Predicted Functional Partners:

LOC100700559

0.926

LOC100698670

0.926

LOC100709454

0.926

LOC102078289

0.926

LOC100693723

0.926

LOC100703463

0.925

aldh16a1

0.925

aldh2

0.925

LOC100706008

0.921

LOC100695823

0.921

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC100534433	LOC100693723	ENSONIP00000036844	ENSONIP00000062318	Aldo-keto reductase family 1, member A1a (aldehyde reductase).	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.926
LOC100534433	LOC100695823	ENSONIP00000036844	ENSONIP00000072525	Aldo-keto reductase family 1, member A1a (aldehyde reductase).	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	0.921
LOC100534433	LOC100698670	ENSONIP00000036844	ENSONIP00000010925	Aldo-keto reductase family 1, member A1a (aldehyde reductase).	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.926
LOC100534433	LOC100700559	ENSONIP00000036844	ENSONIP00000007872	Aldo-keto reductase family 1, member A1a (aldehyde reductase).	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.926
LOC100534433	LOC100703463	ENSONIP00000036844	ENSONIP00000023425	Aldo-keto reductase family 1, member A1a (aldehyde reductase).	Aldehyde dehydrogenase 9 family, member A1b; Belongs to the aldehyde dehydrogenase family.	0.925
LOC100534433	LOC100706008	ENSONIP00000036844	ENSONIP00000070226	Aldo-keto reductase family 1, member A1a (aldehyde reductase).	Zgc:77938.	0.921
LOC100534433	LOC100709454	ENSONIP00000036844	ENSONIP00000035953	Aldo-keto reductase family 1, member A1a (aldehyde reductase).	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.926
LOC100534433	LOC102078289	ENSONIP00000036844	ENSONIP00000054826	Aldo-keto reductase family 1, member A1a (aldehyde reductase).	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.926
LOC100534433	aldh16a1	ENSONIP00000036844	ENSONIP00000037445	Aldo-keto reductase family 1, member A1a (aldehyde reductase).	Aldehyde dehydrogenase 16 family, member A1.	0.925
LOC100534433	aldh2	ENSONIP00000036844	ENSONIP00000050125	Aldo-keto reductase family 1, member A1a (aldehyde reductase).	Aldehyde dehydrogenase 2 family member, tandem duplicate 2; Belongs to the aldehyde dehydrogenase family.	0.925
LOC100693723	LOC100534433	ENSONIP00000062318	ENSONIP00000036844	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Aldo-keto reductase family 1, member A1a (aldehyde reductase).	0.926
LOC100693723	LOC100695823	ENSONIP00000062318	ENSONIP00000072525	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	0.947
LOC100693723	LOC100706008	ENSONIP00000062318	ENSONIP00000070226	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Zgc:77938.	0.947
LOC100695823	LOC100534433	ENSONIP00000072525	ENSONIP00000036844	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Aldo-keto reductase family 1, member A1a (aldehyde reductase).	0.921
LOC100695823	LOC100693723	ENSONIP00000072525	ENSONIP00000062318	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.947
LOC100695823	LOC100698670	ENSONIP00000072525	ENSONIP00000010925	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.947
LOC100695823	LOC100700559	ENSONIP00000072525	ENSONIP00000007872	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.947
LOC100695823	LOC100703463	ENSONIP00000072525	ENSONIP00000023425	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Aldehyde dehydrogenase 9 family, member A1b; Belongs to the aldehyde dehydrogenase family.	0.945
LOC100695823	LOC100706008	ENSONIP00000072525	ENSONIP00000070226	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Zgc:77938.	0.902
LOC100695823	LOC100709454	ENSONIP00000072525	ENSONIP00000035953	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.947

page 1 of 3

Network Stats

number of nodes:

5

number of edges:

5

average node degree:

2

avg. local clustering coefficient:

0.833

expected number of edges:

4

PPI enrichment p-value:

0.377

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006072

glycerol-3-phosphate metabolic process

5 of 12

2.91

5.03

4.40e-10

GO:0019432

Triglyceride biosynthetic process

4 of 13

2.77

3.76

1.03e-07

GO:0006654

Phosphatidic acid biosynthetic process

4 of 17

2.66

3.55

2.15e-07

GO:0008654

Phospholipid biosynthetic process

7 of 183

1.87

3.48

2.42e-09

GO:0046486

Glycerolipid metabolic process

8 of 318

1.69

3.11

1.24e-09

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008374

O-acyltransferase activity

8 of 49

2.5

7.29

7.90e-16

GO:0003841

1-acylglycerol-3-phosphate O-acyltransferase activity

5 of 11

2.94

5.55

4.61e-11

GO:0004366

glycerol-3-phosphate O-acyltransferase activity

4 of 5

3.19

4.79

1.85e-09

GO:0102420

sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity

2 of 2

3.29

1.86

0.00044

GO:0003824

Catalytic activity

11 of 5987

0.55

0.46

0.00030

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009331

glycerol-3-phosphate dehydrogenase complex

2 of 4

2.99

1.24

0.0057

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:31159297

(2019) Functional Analysis of Genes Involved in Glycerolipids Biosynthesis (GPAT1 and GPAT2) in Pigs.

4 of 14

2.74

2.79

7.12e-06

PMID:38003015

(2023) Role of Different Members of the AGPAT Gene Family in Milk Fat Synthesis in Bubalus bubalis.

4 of 17

2.66

2.77

7.12e-06

PMID:29724161

(2018) Transcriptional profiling of swine mammary gland during the transition from colostrogenesis to lactogenesis using RNA sequencing.

5 of 95

2.01

2.29

1.89e-05

PMID:28455945

(2017) The influence of delipidation on triglyceride and LIPIN1 of porcine embryos derived from parthenogenetic activation.

3 of 6

2.99

2.14

0.00013

PMID:36108237

(2022) Identification of a missense variant in the porcine AGPAT gene family associated with intramuscular fat content through whole-genome sequencing.

3 of 8

2.86

2.03

0.00020

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10409

Glycerophospholipid metabolism

10 of 31

2.8

11.45

1.04e-23

CL:10458

glycerol-3-phosphate O-acyltransferase activity, and glycerol-3-phosphate catabolic process

6 of 6

3.29

7.99

2.10e-15

CL:10411

Glycerolipid metabolism

3 of 19

2.48

2.17

8.74e-05

CL:10412

Mixed, incl. Acyltransferase C-terminus, and Diacylglycerol diphosphate phosphatase activity

2 of 11

2.55

1.14

0.0084

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ssc00564

Glycerophospholipid metabolism

11 of 84

2.4

10.09

2.53e-24

ssc00561

Glycerolipid metabolism

7 of 53

2.41

6.33

5.31e-14

ssc01100

Metabolic pathways

8 of 1250

1.09

1.26

2.25e-06

ssc04975

Fat digestion and absorption

2 of 37

2.02

0.97

0.0147

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

SSC-1483166

Synthesis of PA

10 of 38

2.71

11.04

2.18e-23

SSC-1430728

Metabolism

11 of 1426

1.17

1.77

4.08e-11

SSC-75109

Triglyceride biosynthesis

2 of 11

2.55

1.26

0.0050

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009331

glycerol-3-phosphate dehydrogenase complex

2 of 4

2.99

1.18

0.0073

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0012

Acyltransferase

4 of 73

2.03

2.26

2.30e-05

KW-0594

Phospholipid biosynthesis

2 of 10

2.59

1.34

0.0036

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF07479

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus

2 of 3

3.11

1.26

0.0054

PF01210

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus

2 of 3

3.11

1.26

0.0054

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002123

Phospholipid/glycerol acyltransferase

8 of 14

3.04

9.79

3.12e-19

IPR022284

Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase

3 of 4

3.16

2.73

1.11e-05

IPR045520

GPAT/DHAPAT, C-terminal domain

2 of 2

3.29

1.4

0.0030

IPR045252

Lysophosphatidylcholine acyltransferase LPCAT1-like

2 of 4

2.99

1.4

0.0030

IPR041728

GPAT/DHAPAT, acyltransferase domain

2 of 2

3.29

1.4

0.0030

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00563

Phosphate acyltransferases

8 of 19

2.91

9.63

2.83e-19

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