STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mlh1MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (734 aa)    
Predicted Functional Partners:
pms2
PMS1 homolog 2, mismatch repair system component.
  
 
0.999
Mlh3
MutL homolog 3 (E. coli).
    
0.997
msh6
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
 
 0.995
msh2
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
 
 0.994
pms1
PMS1 homolog 1, mismatch repair system component.
  
 
0.988
fan1
Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.
   
 0.986
Exo1
Exonuclease 1.
   
 0.985
brip1
BRCA1 interacting protein C-terminal helicase 1.
   
 0.981
blm
BLM RecQ like helicase.
  
 0.978
I3KAM2_ORENI
MutS homolog 3 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR).
 
 0.974
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.