adam9 protein (Oreochromis niloticus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

adam9

Disintegrin and metalloproteinase domain-containing protein 9 isoform X1. (840 aa)

Predicted Functional Partners:

lipe

0.621

I3JWG9_ORENI

0.587

LOC100705713

0.515

mak16

0.514

ppp2ca

0.501

rsph14

0.489

arhgap21

0.489

LGI2

0.454

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
I3JWG9_ORENI	LOC100705713	ENSONIP00000012707	ENSONIP00000016281	Nuclear receptor subfamily 2, group F, member 6a.	Serine/threonine-protein phosphatase.	0.438
I3JWG9_ORENI	adam9	ENSONIP00000012707	ENSONIP00000050489	Nuclear receptor subfamily 2, group F, member 6a.	Disintegrin and metalloproteinase domain-containing protein 9 isoform X1.	0.587
I3JWG9_ORENI	lipe	ENSONIP00000012707	ENSONIP00000014383	Nuclear receptor subfamily 2, group F, member 6a.	Lipase, hormone-sensitive b.	0.439
I3JWG9_ORENI	ppp2ca	ENSONIP00000012707	ENSONIP00000021778	Nuclear receptor subfamily 2, group F, member 6a.	Serine/threonine-protein phosphatase.	0.438
I3JWG9_ORENI	rsph14	ENSONIP00000012707	ENSONIP00000000691	Nuclear receptor subfamily 2, group F, member 6a.	Uncharacterized protein.	0.438
LGI2	adam9	ENSONIP00000018253	ENSONIP00000050489	Leucine-rich repeat LGI family, member 2b.	Disintegrin and metalloproteinase domain-containing protein 9 isoform X1.	0.454
LOC100705713	I3JWG9_ORENI	ENSONIP00000016281	ENSONIP00000012707	Serine/threonine-protein phosphatase.	Nuclear receptor subfamily 2, group F, member 6a.	0.438
LOC100705713	adam9	ENSONIP00000016281	ENSONIP00000050489	Serine/threonine-protein phosphatase.	Disintegrin and metalloproteinase domain-containing protein 9 isoform X1.	0.515
LOC100705713	ppp2ca	ENSONIP00000016281	ENSONIP00000021778	Serine/threonine-protein phosphatase.	Serine/threonine-protein phosphatase.	0.900
adam9	I3JWG9_ORENI	ENSONIP00000050489	ENSONIP00000012707	Disintegrin and metalloproteinase domain-containing protein 9 isoform X1.	Nuclear receptor subfamily 2, group F, member 6a.	0.587
adam9	LGI2	ENSONIP00000050489	ENSONIP00000018253	Disintegrin and metalloproteinase domain-containing protein 9 isoform X1.	Leucine-rich repeat LGI family, member 2b.	0.454
adam9	LOC100705713	ENSONIP00000050489	ENSONIP00000016281	Disintegrin and metalloproteinase domain-containing protein 9 isoform X1.	Serine/threonine-protein phosphatase.	0.515
adam9	arhgap21	ENSONIP00000050489	ENSONIP00000071770	Disintegrin and metalloproteinase domain-containing protein 9 isoform X1.	Rho GTPase activating protein 21a.	0.489
adam9	lipe	ENSONIP00000050489	ENSONIP00000014383	Disintegrin and metalloproteinase domain-containing protein 9 isoform X1.	Lipase, hormone-sensitive b.	0.621
adam9	mak16	ENSONIP00000050489	ENSONIP00000062268	Disintegrin and metalloproteinase domain-containing protein 9 isoform X1.	Protein MAK16 homolog; Belongs to the MAK16 family.	0.514
adam9	ppp2ca	ENSONIP00000050489	ENSONIP00000021778	Disintegrin and metalloproteinase domain-containing protein 9 isoform X1.	Serine/threonine-protein phosphatase.	0.501
adam9	rsph14	ENSONIP00000050489	ENSONIP00000000691	Disintegrin and metalloproteinase domain-containing protein 9 isoform X1.	Uncharacterized protein.	0.489
arhgap21	adam9	ENSONIP00000071770	ENSONIP00000050489	Rho GTPase activating protein 21a.	Disintegrin and metalloproteinase domain-containing protein 9 isoform X1.	0.489
arhgap21	mak16	ENSONIP00000071770	ENSONIP00000062268	Rho GTPase activating protein 21a.	Protein MAK16 homolog; Belongs to the MAK16 family.	0.590
arhgap21	rsph14	ENSONIP00000071770	ENSONIP00000000691	Rho GTPase activating protein 21a.	Uncharacterized protein.	0.590

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

30

average node degree:

5.45

avg. local clustering coefficient:

0.837

expected number of edges:

14

PPI enrichment p-value:

0.000232

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006259

DNA metabolic process

8 of 108

1.23

1.52

2.10e-06

GO:0006260

DNA replication

4 of 33

1.45

1.2

0.0013

GO:0090304

Nucleic acid metabolic process

9 of 239

0.94

0.95

1.55e-05

GO:0006281

DNA repair

4 of 51

1.26

0.89

0.0056

GO:0006265

DNA topological change

2 of 6

1.89

0.81

0.0285

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003918

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

2 of 4

2.06

0.86

0.0243

GO:0008408

3-5 exonuclease activity

2 of 8

1.76

0.83

0.0243

GO:0003677

DNA binding

7 of 185

0.94

0.76

0.0017

GO:0140097

Catalytic activity, acting on DNA

4 of 65

1.15

0.66

0.0243

GO:0003676

Nucleic acid binding

8 of 327

0.75

0.58

0.0026

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2559

Mixed, incl. AAA domain, and Regulation of catalytic activity

3 of 5

2.14

1.66

0.00062

CL:2546

Mostly uncharacterized, incl. Bacterial nucleoid, and AAA domain

4 of 17

1.73

1.57

0.00041

CL:2496

Mostly uncharacterized, incl. DNA recombination, and Protein of unknown function DUF4252

5 of 42

1.44

1.35

0.00041

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

fba03440

Homologous recombination

4 of 20

1.66

1.64

0.00019

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0043590

Bacterial nucleoid

3 of 7

1.99

1.42

0.0017

GOCC:0005622

Intracellular

10 of 881

0.42

0.31

0.0157

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0235

DNA replication

4 of 14

1.82

1.86

9.99e-05

KW-0234

DNA repair

4 of 28

1.52

1.37

0.00057

KW-0238

DNA-binding

5 of 79

1.16

1.04

0.00061

KW-0239

DNA-directed DNA polymerase

2 of 7

1.82

0.86

0.0214

KW-0963

Cytoplasm

5 of 189

0.78

0.49

0.0229

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006171

TOPRIM domain

3 of 5

2.14

1.31

0.0032

IPR018522

DNA topoisomerase, type IIA, conserved site

2 of 2

2.36

0.72

0.0481

IPR013759

DNA topoisomerase, type IIA, subunit B, C-terminal

2 of 2

2.36

0.72

0.0481

IPR013506

DNA topoisomerase, type IIA, subunit B, domain 2

2 of 2

2.36

0.72

0.0481

IPR003395

RecF/RecN/SMC, N-terminal

2 of 2

2.36

0.72

0.0481

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00433

TopoisomeraseII

2 of 2

2.36

1.15

0.0076

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (28%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About