Aqp11 protein (Oreochromis niloticus) - STRING interaction network

Nodes:

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

Aqp11

Aquaporin 11. (267 aa)

Predicted Functional Partners:

LOC100704311

0.737

aqp10

0.732

LOC109202395

0.700

LOC100690637

0.700

sumo2

0.700

ENSONIP00000064374

0.700

LOC100709166

0.700

sumo1

0.700

LOC100703924

0.684

LOC100702556

0.661

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Aqp11	ENSONIP00000064374	ENSONIP00000056486	ENSONIP00000064374	Aquaporin 11.	Small ubiquitin-related modifier 2.	0.700
Aqp11	LOC100690637	ENSONIP00000056486	ENSONIP00000037316	Aquaporin 11.	Small ubiquitin-related modifier.	0.700
Aqp11	LOC100702556	ENSONIP00000056486	ENSONIP00000007893	Aquaporin 11.	Aquaporin 10a; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.661
Aqp11	LOC100703924	ENSONIP00000056486	ENSONIP00000038095	Aquaporin 11.	Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.684
Aqp11	LOC100704311	ENSONIP00000056486	ENSONIP00000024897	Aquaporin 11.	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.737
Aqp11	LOC100709166	ENSONIP00000056486	ENSONIP00000068525	Aquaporin 11.	Small ubiquitin-related modifier.	0.700
Aqp11	LOC109202395	ENSONIP00000056486	ENSONIP00000034808	Aquaporin 11.	Small ubiquitin-related modifier 2.	0.700
Aqp11	aqp10	ENSONIP00000056486	ENSONIP00000024860	Aquaporin 11.	Aquaporin 10b; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.732
Aqp11	sumo1	ENSONIP00000056486	ENSONIP00000072692	Aquaporin 11.	Small ubiquitin-related modifier.	0.700
Aqp11	sumo2	ENSONIP00000056486	ENSONIP00000062917	Aquaporin 11.	Small ubiquitin-related modifier.	0.700
ENSONIP00000064374	Aqp11	ENSONIP00000064374	ENSONIP00000056486	Small ubiquitin-related modifier 2.	Aquaporin 11.	0.700
ENSONIP00000064374	sumo1	ENSONIP00000064374	ENSONIP00000072692	Small ubiquitin-related modifier 2.	Small ubiquitin-related modifier.	0.655
LOC100690637	Aqp11	ENSONIP00000037316	ENSONIP00000056486	Small ubiquitin-related modifier.	Aquaporin 11.	0.700
LOC100690637	sumo1	ENSONIP00000037316	ENSONIP00000072692	Small ubiquitin-related modifier.	Small ubiquitin-related modifier.	0.655
LOC100702556	Aqp11	ENSONIP00000007893	ENSONIP00000056486	Aquaporin 10a; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin 11.	0.661
LOC100702556	LOC100704311	ENSONIP00000007893	ENSONIP00000024897	Aquaporin 10a; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.543
LOC100703924	Aqp11	ENSONIP00000038095	ENSONIP00000056486	Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin 11.	0.684
LOC100703924	LOC100704311	ENSONIP00000038095	ENSONIP00000024897	Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family.	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.566
LOC100704311	Aqp11	ENSONIP00000024897	ENSONIP00000056486	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin 11.	0.737
LOC100704311	LOC100702556	ENSONIP00000024897	ENSONIP00000007893	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin 10a; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.543

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Network Stats

number of nodes:

6

number of edges:

9

average node degree:

3

avg. local clustering coefficient:

0.8

expected number of edges:

8

PPI enrichment p-value:

0.412

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000387

Spliceosomal snRNP assembly

4 of 30

2.45

2.86

3.49e-06

GO:0040031

snRNA modification

3 of 8

2.9

2.63

1.54e-05

GO:0008380

RNA splicing

6 of 351

1.55

1.92

9.26e-06

GO:0000398

mRNA splicing, via spliceosome

5 of 229

1.66

1.86

4.08e-05

GO:0016071

mRNA metabolic process

7 of 575

1.41

1.78

3.85e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017069

snRNA binding

7 of 39

2.58

6.59

6.85e-14

GO:0017070

U6 snRNA binding

4 of 8

3.02

4.21

1.86e-08

GO:0003723

RNA binding

9 of 1208

1.19

1.57

1.37e-07

GO:0097322

7SK snRNA binding

2 of 5

2.92

1.46

0.0023

GO:1901363

Heterocyclic compound binding

10 of 6430

0.51

0.37

0.0105

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030532

Small nuclear ribonucleoprotein complex

5 of 59

2.25

3.5

8.06e-08

GO:0046540

U4/U6 x U5 tri-snRNP complex

4 of 32

2.42

3.19

6.88e-07

GO:0015030

Cajal body

4 of 36

2.37

3.17

6.88e-07

GO:0071005

U2-type precatalytic spliceosome

4 of 48

2.24

2.95

1.35e-06

GO:1990904

Ribonucleoprotein complex

7 of 598

1.39

1.89

6.88e-07

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:19743

Regulation of protein localization to Cajal body, and U6 snRNA 3-end binding

4 of 6

3.15

4.14

2.82e-08

CL:18977

Small nuclear ribonucleoprotein complex, and snRNA binding

5 of 66

2.2

3.24

2.60e-07

CL:19047

Spliceosomal tri-snRNP complex assembly, and U4/U6 x U5 tri-snRNP complex

3 of 10

2.8

2.65

1.34e-05

CL:18979

Spliceosomal snRNP complex, and snRNA binding

4 of 60

2.15

2.46

1.20e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03040

Spliceosome

4 of 266

1.5

1.26

0.0011

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

5 of 391

1.43

1.31

0.00051

MAP-8953854

Metabolism of RNA

7 of 946

1.19

1.21

9.46e-05

MAP-72163

mRNA Splicing - Major Pathway

4 of 272

1.49

1.09

0.0034

MAP-72172

mRNA Splicing

4 of 296

1.45

1.06

0.0036

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990904

Ribonucleoprotein complex

7 of 447

1.52

2.16

5.13e-07

GOCC:0005634

Nucleus

8 of 3501

0.68

0.43

0.0232

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