STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Pik3cbPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1085 aa)    
Predicted Functional Partners:
pdpk1
3-phosphoinositide dependent protein kinase 1b.
   
 0.961
hras
HRas proto-oncogene, GTPase a.
   
 0.948
LOC100707394
PH domain-containing protein.
    
 0.943
LOC100707819
Erb-b2 receptor tyrosine kinase 3b.
    
 0.941
kdr
Kinase insert domain receptor (a type III receptor tyrosine kinase); Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
    
 0.938
mtor
Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.
    
0.934
LOC100706013
Inositol polyphosphate phosphatase-like 1b.
   
 
 0.921
inppl1
Inositol polyphosphate phosphatase-like 1a.
   
 
 0.921
pgr
Progesterone receptor.
   
 0.919
met
MET proto-oncogene, receptor tyrosine kinase.
    
 0.870
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.