LOC100696545 protein (Oreochromis niloticus)

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Known Interactions

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Predicted Interactions

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[Homology]

Score

LOC100696545

Apoptosis-associated tyrosine kinase a. (1614 aa)

Predicted Functional Partners:

il34

0.535

LOC100707172

0.508

kitlg

0.487

LOC100696773

0.470

grb2

0.434

gdnf

0.418

I3KWA4_ORENI

0.416

LOC100712331

0.400

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
I3KWA4_ORENI	LOC100696545	ENSONIP00000025400	ENSONIP00000078432	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Apoptosis-associated tyrosine kinase a.	0.416
LOC100696545	I3KWA4_ORENI	ENSONIP00000078432	ENSONIP00000025400	Apoptosis-associated tyrosine kinase a.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.416
LOC100696545	LOC100696773	ENSONIP00000078432	ENSONIP00000053979	Apoptosis-associated tyrosine kinase a.	Uncharacterized protein.	0.470
LOC100696545	LOC100707172	ENSONIP00000078432	ENSONIP00000010774	Apoptosis-associated tyrosine kinase a.	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family.	0.508
LOC100696545	LOC100712331	ENSONIP00000078432	ENSONIP00000071817	Apoptosis-associated tyrosine kinase a.	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family.	0.400
LOC100696545	gdnf	ENSONIP00000078432	ENSONIP00000061493	Apoptosis-associated tyrosine kinase a.	Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake.	0.418
LOC100696545	grb2	ENSONIP00000078432	ENSONIP00000064237	Apoptosis-associated tyrosine kinase a.	Growth factor receptor-bound protein 2b.	0.434
LOC100696545	il34	ENSONIP00000078432	ENSONIP00000039260	Apoptosis-associated tyrosine kinase a.	Interleukin 34.	0.535
LOC100696545	kitlg	ENSONIP00000078432	ENSONIP00000004882	Apoptosis-associated tyrosine kinase a.	Kit ligand a.	0.487
LOC100696773	LOC100696545	ENSONIP00000053979	ENSONIP00000078432	Uncharacterized protein.	Apoptosis-associated tyrosine kinase a.	0.470
LOC100696773	gdnf	ENSONIP00000053979	ENSONIP00000061493	Uncharacterized protein.	Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake.	0.432
LOC100696773	grb2	ENSONIP00000053979	ENSONIP00000064237	Uncharacterized protein.	Growth factor receptor-bound protein 2b.	0.410
LOC100696773	il34	ENSONIP00000053979	ENSONIP00000039260	Uncharacterized protein.	Interleukin 34.	0.964
LOC100696773	kitlg	ENSONIP00000053979	ENSONIP00000004882	Uncharacterized protein.	Kit ligand a.	0.426
LOC100707172	LOC100696545	ENSONIP00000010774	ENSONIP00000078432	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family.	Apoptosis-associated tyrosine kinase a.	0.508
LOC100707172	grb2	ENSONIP00000010774	ENSONIP00000064237	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family.	Growth factor receptor-bound protein 2b.	0.419
LOC100712331	LOC100696545	ENSONIP00000071817	ENSONIP00000078432	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family.	Apoptosis-associated tyrosine kinase a.	0.400
LOC100712331	grb2	ENSONIP00000071817	ENSONIP00000064237	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family.	Growth factor receptor-bound protein 2b.	0.419
gdnf	LOC100696545	ENSONIP00000061493	ENSONIP00000078432	Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake.	Apoptosis-associated tyrosine kinase a.	0.418
gdnf	LOC100696773	ENSONIP00000061493	ENSONIP00000053979	Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake.	Uncharacterized protein.	0.432

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Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

12

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0071973

Bacterial-type flagellum-dependent cell motility

6 of 19

1.97

3.21

6.14e-08

GO:0006935

Chemotaxis

3 of 7

2.1

1.58

0.00087

GO:0044781

Bacterial-type flagellum organization

3 of 12

1.87

1.35

0.0020

GO:0009306

Protein secretion

3 of 14

1.8

1.27

0.0027

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003774

Cytoskeletal motor activity

5 of 7

2.32

3.56

8.39e-08

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009288

Bacterial-type flagellum

9 of 23

2.06

5.81

1.66e-15

GO:0009425

Bacterial-type flagellum basal body

8 of 17

2.14

5.76

2.31e-14

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3168

Cilium

10 of 17

2.24

7.48

1.21e-18

CL:3165

Cilium, and Proton channel activity

11 of 36

1.96

6.06

1.21e-18

CL:3191

Cytoskeletal motor activity

5 of 5

2.47

4.33

3.20e-09

CL:3169

Flagellar basal body rod FlgEFG protein C-terminal, and Bacterial-type flagellum assembly

4 of 11

2.03

2.48

7.19e-06

CL:3181

Bacterial flagellum protein export, and Bacterial-type flagellum assembly

2 of 5

2.07

0.97

0.0150

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

otm02040

Flagellar assembly

8 of 25

1.98

4.76

7.65e-13

otm02030

Bacterial chemotaxis

2 of 6

1.99

0.95

0.0154

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009288

Bacterial-type flagellum

9 of 28

1.98

5.21

1.67e-14

GOCC:0009425

Bacterial-type flagellum basal body

7 of 18

2.06

4.58

1.89e-11

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0282

Flagellum

8 of 25

1.98

4.68

1.47e-12

KW-0975

Bacterial flagellum

3 of 9

1.99

1.75

0.00032

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01052

Type III flagellar switch regulator (C-ring) FliN C-term

2 of 2

2.47

0.84

0.0298

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