Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SEA12437.1Phosphomethylpyrimidine synthase. (428 aa)    
Predicted Functional Partners:
SEA12399.1
Phosphomethylpyrimidine synthase.
 
  
 
0.941
SEA46697.1
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase.
  
 
 0.934
thiE
Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
 
 0.856
SEA12335.1
Predicted metal-binding protein.
    
  0.832
SEA70199.1
Thiazole-phosphate synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.813
SEA47658.1
Adenylyltransferase and sulfurtransferase.
  
  
 0.810
SEA70142.1
Thiamine-phosphate pyrophosphorylase.
  
 
 0.809
SEA70249.1
Sulfur carrier protein ThiS.
  
  
 0.770
SEA46116.1
Iron-only hydrogenase maturation protein HydG.
  
  
 0.745
SEA70171.1
Tyrosine lyase ThiH.
  
  
 0.745
Your Current Organism:
Eubacterium aggregans
NCBI taxonomy Id: 81409
Other names: DSM 12183, E. aggregans, Eubacterium aggregans Mechichi et al. 2000, strain SR12
Server load: medium (50%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.