Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SEA69598.1Pheromone shutdown-related protein TraB. (391 aa)    
Predicted Functional Partners:
SEA79973.1
Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II.
    
   0.807
SEA47942.1
NADH-quinone oxidoreductase subunit F.
    
   0.806
SEA26371.1
NAD(P)-dependent iron-only hydrogenase diaphorase component flavoprotein.
    
   0.798
SEA69624.1
Transcriptional regulator, LacI family.
       0.776
SEA69646.1
Aromatic-amino-acid transaminase.
       0.722
SEA69674.1
Fumarate hydratase subunit beta.
       0.707
SEA69690.1
Fumarate hydratase subunit alpha.
       0.707
mprF
Hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.
       0.703
SEA69575.1
Amino acid ABC transporter substrate-binding protein, PAAT family.
       0.535
SEA69745.1
tRNA (cytidine/uridine-2'-O-)-methyltransferase; Could methylate the ribose at the nucleotide 34 wobble position in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
       0.454
Your Current Organism:
Eubacterium aggregans
NCBI taxonomy Id: 81409
Other names: DSM 12183, E. aggregans, Eubacterium aggregans Mechichi et al. 2000, strain SR12
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