Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SEA78465.1Molecular chaperone DnaJ. (217 aa)    
Predicted Functional Partners:
dnaK-2
Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
 0.997
dnaK
Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
 0.991
htpG
Molecular chaperone HtpG; Molecular chaperone. Has ATPase activity.
  
 0.981
SEA47942.1
NADH-quinone oxidoreductase subunit F.
  
 0.952
grpE
Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...]
 
 
 0.950
SEA79973.1
Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II.
 
 
 0.947
SEA26371.1
NAD(P)-dependent iron-only hydrogenase diaphorase component flavoprotein.
   
  0.941
SEA78447.1
Hypothetical protein.
 
     0.917
groL
Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
 
 0.914
SEA47191.1
Thioredoxin; Belongs to the thioredoxin family.
  
 
 0.865
Your Current Organism:
Eubacterium aggregans
NCBI taxonomy Id: 81409
Other names: DSM 12183, E. aggregans, Eubacterium aggregans Mechichi et al. 2000, strain SR12
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