Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
atf3Activating transcription factor 3. (210 aa)    
Predicted Functional Partners:
LOC102290252
JunE proto-oncogene, AP-1 transcription factor subunit.
   
 0.997
ENSHBUP00000016109
Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.
   
 0.997
ddit3
DNA-damage-inducible transcript 3.
   
 0.989
atf4
Activating transcription factor 4a.
    
 0.988
LOC102296334
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.982
mdm2
MDM2 proto-oncogene.
    
 
 0.979
LOC102296778
Activating transcription factor 4b.
    
 0.964
LOC102297012
CCAAT enhancer binding protein beta.
   
 0.963
MXI1
MAX interactor 1, dimerization protein.
      
 0.958
LOC102306464
V-fos FBJ murine osteosarcoma viral oncogene homolog Ab.
   
 0.945
Your Current Organism:
Haplochromis burtoni
NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni
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