STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hace1HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1. (903 aa)    
Predicted Functional Partners:
LOC102314666
Ubiquitin-like domain-containing protein.
   
 0.900
rps27a
Ribosomal protein S27a.
   
 0.845
trip12
Thyroid hormone receptor interactor 12.
   
 
0.806
ubb
Ubiquitin-like domain-containing protein.
    
 0.782
uba52
Ubiquitin A-52 residue ribosomal protein fusion product 1.
    
 0.782
fau
40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.
   
 0.751
ddit4
DNA-damage-inducible transcript 4.
    
   0.739
trrap
Transformation/transcription domain-associated protein; Belongs to the PI3/PI4-kinase family.
   
 
 0.720
atg7
Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]
    
 0.663
LOC102296658
Ubiquitin-like domain-containing protein.
   
 0.645
Your Current Organism:
Haplochromis burtoni
NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni
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