herc1 protein (Haplochromis burtoni) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

herc1

HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. (4350 aa)

Predicted Functional Partners:

rnf8

0.818

UBE3A

0.722

ranbp2

0.720

LOC102314666

0.687

brca1

0.686

ube3a

0.685

pias4

0.684

rps27a

0.660

zfand4

0.647

bard1

0.643

Your Current Organism:

Haplochromis burtoni

NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC102314666	UBE3A	ENSHBUP00000031002	ENSHBUP00000021910	Ubiquitin-like domain-containing protein.	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	0.718
LOC102314666	bard1	ENSHBUP00000031002	ENSHBUP00000000997	Ubiquitin-like domain-containing protein.	BRCA1 associated RING domain 1.	0.946
LOC102314666	brca1	ENSHBUP00000031002	ENSHBUP00000003104	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.830
LOC102314666	herc1	ENSHBUP00000031002	ENSHBUP00000021091	Ubiquitin-like domain-containing protein.	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1.	0.687
LOC102314666	pias4	ENSHBUP00000031002	ENSHBUP00000024487	Ubiquitin-like domain-containing protein.	Protein inhibitor of activated STAT, 4a.	0.700
LOC102314666	rnf8	ENSHBUP00000031002	ENSHBUP00000016268	Ubiquitin-like domain-containing protein.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.969
LOC102314666	rps27a	ENSHBUP00000031002	ENSHBUP00000002167	Ubiquitin-like domain-containing protein.	Ribosomal protein S27a.	0.998
LOC102314666	ube3a	ENSHBUP00000031002	ENSHBUP00000013050	Ubiquitin-like domain-containing protein.	Ubiquitin protein ligase E3A.	0.680
LOC102314666	zfand4	ENSHBUP00000031002	ENSHBUP00000035149	Ubiquitin-like domain-containing protein.	Zinc finger, AN1-type domain 4.	0.507
UBE3A	LOC102314666	ENSHBUP00000021910	ENSHBUP00000031002	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	Ubiquitin-like domain-containing protein.	0.718
UBE3A	herc1	ENSHBUP00000021910	ENSHBUP00000021091	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1.	0.722
UBE3A	rps27a	ENSHBUP00000021910	ENSHBUP00000002167	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	Ribosomal protein S27a.	0.570
UBE3A	ube3a	ENSHBUP00000021910	ENSHBUP00000013050	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	Ubiquitin protein ligase E3A.	0.852
UBE3A	zfand4	ENSHBUP00000021910	ENSHBUP00000035149	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	Zinc finger, AN1-type domain 4.	0.536
bard1	LOC102314666	ENSHBUP00000000997	ENSHBUP00000031002	BRCA1 associated RING domain 1.	Ubiquitin-like domain-containing protein.	0.946
bard1	brca1	ENSHBUP00000000997	ENSHBUP00000003104	BRCA1 associated RING domain 1.	Uncharacterized protein.	0.999
bard1	herc1	ENSHBUP00000000997	ENSHBUP00000021091	BRCA1 associated RING domain 1.	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1.	0.643
bard1	pias4	ENSHBUP00000000997	ENSHBUP00000024487	BRCA1 associated RING domain 1.	Protein inhibitor of activated STAT, 4a.	0.802
bard1	ranbp2	ENSHBUP00000000997	ENSHBUP00000022471	BRCA1 associated RING domain 1.	RAN binding protein 2.	0.487
bard1	rnf8	ENSHBUP00000000997	ENSHBUP00000016268	BRCA1 associated RING domain 1.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.846