GAN protein (Astatotilapia calliptera) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

GAN

Gigaxonin. (603 aa)

Predicted Functional Partners:

tbcb

0.940

LOC113036190

0.913

CUL3

0.913

rbx1

0.831

cul1

0.773

wdr76

0.710

commd9

0.698

commd5

0.698

LOC113035354

0.676

ENSACLP00000024993

0.676

Your Current Organism:

Astatotilapia calliptera

NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy

Export your current network:

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same PNG format, but at higher resolution

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SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

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TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUL3	GAN	ENSACLP00000040546	ENSACLP00000001197	Cullin 3; Belongs to the cullin family.	Gigaxonin.	0.913
CUL3	commd5	ENSACLP00000040546	ENSACLP00000032231	Cullin 3; Belongs to the cullin family.	COMM domain containing 5.	0.591
CUL3	commd9	ENSACLP00000040546	ENSACLP00000024109	Cullin 3; Belongs to the cullin family.	COMM domain containing 9.	0.589
CUL3	cul1	ENSACLP00000040546	ENSACLP00000034014	Cullin 3; Belongs to the cullin family.	Cullin 1b; Belongs to the cullin family.	0.945
CUL3	rbx1	ENSACLP00000040546	ENSACLP00000020852	Cullin 3; Belongs to the cullin family.	Ring-box 1, E3 ubiquitin protein ligase.	0.992
ENSACLP00000024993	GAN	ENSACLP00000024993	ENSACLP00000001197	Neurofilament, light polypeptide b; Belongs to the intermediate filament family.	Gigaxonin.	0.676
GAN	CUL3	ENSACLP00000001197	ENSACLP00000040546	Gigaxonin.	Cullin 3; Belongs to the cullin family.	0.913
GAN	ENSACLP00000024993	ENSACLP00000001197	ENSACLP00000024993	Gigaxonin.	Neurofilament, light polypeptide b; Belongs to the intermediate filament family.	0.676
GAN	LOC113035354	ENSACLP00000001197	ENSACLP00000022119	Gigaxonin.	IF rod domain-containing protein; Belongs to the intermediate filament family.	0.676
GAN	LOC113036190	ENSACLP00000001197	ENSACLP00000010678	Gigaxonin.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.913
GAN	commd5	ENSACLP00000001197	ENSACLP00000032231	Gigaxonin.	COMM domain containing 5.	0.698
GAN	commd9	ENSACLP00000001197	ENSACLP00000024109	Gigaxonin.	COMM domain containing 9.	0.698
GAN	cul1	ENSACLP00000001197	ENSACLP00000034014	Gigaxonin.	Cullin 1b; Belongs to the cullin family.	0.773
GAN	rbx1	ENSACLP00000001197	ENSACLP00000020852	Gigaxonin.	Ring-box 1, E3 ubiquitin protein ligase.	0.831
GAN	tbcb	ENSACLP00000001197	ENSACLP00000023295	Gigaxonin.	Tubulin folding cofactor B.	0.940
GAN	wdr76	ENSACLP00000001197	ENSACLP00000019752	Gigaxonin.	WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family.	0.710
LOC113035354	GAN	ENSACLP00000022119	ENSACLP00000001197	IF rod domain-containing protein; Belongs to the intermediate filament family.	Gigaxonin.	0.676
LOC113036190	GAN	ENSACLP00000010678	ENSACLP00000001197	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Gigaxonin.	0.913
LOC113036190	commd5	ENSACLP00000010678	ENSACLP00000032231	CULLIN_2 domain-containing protein; Belongs to the cullin family.	COMM domain containing 5.	0.591
LOC113036190	commd9	ENSACLP00000010678	ENSACLP00000024109	CULLIN_2 domain-containing protein; Belongs to the cullin family.	COMM domain containing 9.	0.589