Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LOC113029200Forkhead box I3b. (392 aa)    
Predicted Functional Partners:
suox
Sulfite oxidase.
     
  0.765
sgk3
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
 0.742
gcm2
GCM domain-containing protein.
   
 
 0.696
LOC113023444
Furin (paired basic amino acid cleaving enzyme) a; Belongs to the peptidase S8 family.
     
 0.636
tp63
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.635
edn1
Endothelin 1.
      
 0.613
furin
Furin (paired basic amino acid cleaving enzyme) b; Belongs to the peptidase S8 family.
     
 0.584
traf6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.580
LOC113033463
Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.
     
 0.573
PLK1
Serine/threonine-protein kinase PLK.
   
 0.569
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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