Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ndrg2NDRG family member 2. (368 aa)    
Predicted Functional Partners:
fam162a
Family with sequence similarity 162 member A.
    
 
 0.627
LOC113018712
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.534
eef2k
Eukaryotic elongation factor 2 kinase.
      
 0.499
ENSACLP00000040178
Cardiolipin synthase 1.
     
  0.480
tmx2
Thioredoxin-related transmembrane protein 2a.
    
   0.458
TMX2
Thioredoxin domain-containing protein.
    
   0.458
ENSACLP00000016982
J domain-containing protein.
     
 0.434
dnajb11
DnaJ heat shock protein family (Hsp40) member B11.
     
 0.434
ENSACLP00000002417
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta).
    
 0.428
agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3.
    
 0.428
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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