Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
clcn6Chloride channel 6; Belongs to the chloride channel (TC 2.A.49) family. (866 aa)    
Predicted Functional Partners:
ostm1
Osteoclastogenesis associated transmembrane protein 1.
    
 0.986
cd63
Tetraspanin.
     
  0.765
med19
Mediator of RNA polymerase II transcription subunit 19; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
      
 0.676
ENSACLP00000029759
PRP3 pre-mRNA processing factor 3 homolog (yeast).
      
 0.668
G6PD
Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.
     
 0.660
gpaa1
Glycosylphosphatidylinositol anchor attachment 1.
   
  
 0.611
ENSACLP00000039878
CLN5 intracellular trafficking protein.
      
 0.604
ENSACLP00000024440
Chloride channel, nucleotide-sensitive, 1A.
      
 0.597
tepsin
TEPSIN adaptor related protein complex 4 accessory protein.
      
 0.588
ocrl
OCRL inositol polyphosphate-5-phosphatase.
      
 0.584
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.