Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LOC113032285Cytochrome P450, family 21, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family. (525 aa)    
Predicted Functional Partners:
LOC113026744
Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]
  
0.939
ENSACLP00000030400
Cytochrome P450, family 11, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family.
  
0.939
LOC113026834
Hydroxysteroid (11-beta) dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 0.934
LOC113007739
Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family.
  
 0.929
ENSACLP00000022184
Hydroxysteroid (17-beta) dehydrogenase 3.
   
 0.924
LOC113010228
Cytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family.
  
  
 0.908
LOC113023525
3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
     
 0.896
srd5a1
3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
     
 0.896
srd5a2
3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
     
 0.896
LOC113024447
Cytochrome P450, family 3, subfamily A, polypeptide 65; Belongs to the cytochrome P450 family.
  
0.885
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.